A first dose with Pfizer, a second with Moderna… or vice versa. On April 9, the Minister of Health Olivier Véran raised the possibility of rendering “interchangeable“these two messenger RNA vaccines. The goal:”simplify“the vaccination campaign against Covid-19.

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A 2nd different dose for AstraZeneca

Earlier today, the High Authority for Health (HAS) had confirmed that those under 55 vaccinated against covid-19 with a first dose of AstraZeneca will have their second with Pfizer or Moderna.

Obviously wishing to go further, Olivier Véran indicated having “seized scientists“of the issue of the interchangeability of messenger RNA vaccines, Pfizer and Moderna.

Effectiveness and risks under study

We will see, scientists are starting to tell us that they are interchangeable“, he declared while exchanging with health professionals during a visit to a large vaccination center opened on April 9 in Grenoble.

They are telling us that if we do one or the other in the first or second injection, it’s the same mechanics.“, continued the minister, arguing that that”would simplify“the organization of vaccination.

I am waiting for an immediate response from the health authorities“to validate this,”if it does not present any risks and that it is the effectiveness which is at the rendezvous“.

WHO does not recommend interchangeability

Because for the moment, very little information is available on the subject. The World Health Organization (WHO) has already indicated that it does not have “adequate data“on the interchangeability of vaccines and that its experts therefore did not recommend it”at this stage“.

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Last March, a publication of JAMA was already asking the question of the interchangeability of vaccines. She recognized that no data allowed for the time being “whether such a mixture would be effective “ but that several studies were underway to examine the effectiveness of the combinations.

And for the authors of this publication, these mixtures could in theory “strengthen protection against covid“.